The club has yet to provide an explanation for why the 21-year-old walked away, with rumors swirling that Mosele had attended a traditional ceremony.
According to recent reports, Mosele may have had an anxiety attack as a result of the pressures of high-level professional football.
Mosele was set to win his first senior national team cap after joining the Buccaneers from Baroka FC at the start of the season.
Meanwhile, Ben Motshwari, a midfielder for the Pirates, has been suspended following assault claims made by his girlfriend.
Due to a lack of evidence, the charges were eventually reported to have been dropped.
The Orlando Pirates have yet to provide any additional information about the 30-year-current old's situation.
Malawian striker Gabadinho Mhango made news three weeks ago after an alleged incident in which he was held after failing to pay an eye-watering R26 000 bill at Club Propaganda.
Soon after the claimed incident, video photos of Mhango in the nightclub began to circulate. Mhango hasn't played in the Pirates' last four games.
Last year, star guy Thembinkosi Lorch was also detained and released on R2000 bond after his girlfriend filed an assault charge against him.
He was accused with causing serious bodily harm with the intent to kill, but the charges were eventually dropped in Randburg Magistrates Court pending further investigation.
Following his prior suspension for suspected violence, midfielder Ben Motshwari is said to have started training sessions with the Orlando Pirates.
Motshwari is now expected to be in contention for Pirates' next trip to KwaZulu-Natal, where they will face Maritzburg United in a DStv Premiership match.
On October 20, Pirates, who are now sixth in the league rankings, will meet Ernst Middendorp's Maritzburg side at the Harry Gwala Stadium in an attempt to get back on track.
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