David Alaba and Lucas Vazquez gave Madrid a 2-0 lead before Sergio Aguero grabbed a late reassurance for Barca profound into added time.
The loss was Barca's fourth continuous Clasico rout across all rivalries - their longest losing run in the apparatus since seven misfortunes in succession between April 1962 and February 1965.
Busquets, 33, felt that the Blaugrana ought not to have wound up on the losing side, yet were scattered by yielding the main objective.
"They got it squarely in the initial segment and we didn't," Busquets said to Barca TV post-match. "We realized they planned to allow us to have the ball however they had speed with Rodrigo and Vinicius.
"In a group with these attributes, when you lose the ball it is hard to recuperate. What's more, they have scored an objective in a kick, not in a play. That changes the game. I don't think we had the right to lose, yet that is football.
"When there are rounds of these attributes, the person who scores initially enjoys the benefit. In the subsequent half, we had ownership and control, yet we had not clarified possibilities."
Busquets wouldn't fault the official for the outcome and demanded that Barca stay positive notwithstanding being five focuses behind the best three.
"Indeed, I have seen [the dubious incidents], yet it doesn't make any difference," Busquets continued. "The ref has been acceptable overall lines and I won't react to the discussions.
"A little hole [in the table] is opening however I think we are developing gradually. Presently we will recuperate Ousmane who will give us things in the assault. We need to proceed."
Barca lead trainer Ronald Koeman - who has now lost five games against Real Madrid (three) and Atletico Madrid (two), as numerous as in the past nine seasons in the opposition - agreed with his veteran midfielder, demanding that his men played well yet that going behind permitted their adversaries to play on the break.
"It is consistently hard to comprehend an outcome like this since we made benefits to having another outcome, particularly in the primary half," Koeman said.
"It relied upon an exceptionally clear opportunity to have 1-0 and on second thought, they scored 0-1, then, at that point, it was convoluted because they guarded the outcome and we realized that is very perilous.
"The group was extraordinary as late as possible, we attempted yet we didn't get the outcome we needed. We were acceptable in the primary half. We had a great deal of ball ownership."
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