Fellow Barcelona signing Franck Kessie was introduced in the second half along with reported Manchester United target Frenkie de Jong, as Xavi's charges held out for the win.
Lewandowski, Ansu Fati, and Raphinha, a Brazilian international, made up Xavi Hernandez's front three.
View footage from El Clasico in Las Vegas by scrolling through the slideshow above.
With Antonio Rudiger and Aurélien Tchouaméni making their debuts, this was Los Blancos' first preseason match of their America tour.
While Lewandowski was the centre of attention, Raphinha was the signing who put the game to rest by scoring with a beautiful strike from the edge of the box.
At Lambeau Field, Manchester City defeated Bundesliga champion Bayern Munich in another battle of the titans.
Sadio Mane, Bayern's prized acquisition, was absent since he was in Morocco this week for the CAF awards.
While Kalvin Philipps and Julián Llvarez started the game on the bench, Pep Guardiola was able to unleash Haaland in a Man City uniform.
Similar to El Clasico in Las Vegas, this match was decided in the first half when Haaland scored the lone goal with a close-range finish in the 12th minute.
Both teams will now focus on their upcoming competitive matches, with City playing Liverpool in the Community Shield and Bayern playing RB Leipzig in the German Super Cup, the following weekend.
After crushing rival Chelsea 4-0 in the Florida Cup final at Camping World Stadium, Arsenal maintained their outstanding preseason campaign there.
The Gunners also relied on their recent additions, Gabriel Jesus and Oleksandr Zinchenko, while the Blues started high-profile acquisition Raheem Sterling and kept Kalidou Koulibaly on the bench.
Jesus, who has had a strong preseason tour, scored once more as he started the game before Martin Odegaard added a second to give the Gunners a comfortable lead at the half.
The Blues' problems were only just beginning for Mikel Arteta's team, and they added to them late in the second period when Bukayo Saka and an Albert Sambi Lokonga goal in overtime placed the cherry on top.
Lewandowski debuts as Barca sink Real https://www.kickoff.com/news/articles/world-news/categories/news/world-news/robert-lewandowski-debuts-as-barcelona-sink-real-madrid/721046?gallery=721046&gallery-page=8
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